Interleukin 10/ Interleukin-10R Mutations Causing Very Early Onset Inflammatory Bowel Disease
نویسندگان
چکیده
منابع مشابه
IL-10 and IL-10 Receptor Mutations in Very Early Onset Inflammatory Bowel Disease
Very early onset inflammatory bowel disease (VEO-IBD) is a unique disease entity with a complex genetic susceptibility in affected patients. Next-generation gene sequencing techniques have revealed various monogenetic mutations contributing to the pathogenesis of VEO-IBD, including interleukin 10 (IL-10) and IL-10 receptor (IL-10R) mutations. In this article, we reviewed the features of and eff...
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BACKGROUND AND AIMS Defects in the interleukin 10 (IL-10) signalling pathway have been shown to cause very early onset inflammatory bowel disease (IBD). We report a patient with severe infantile-onset IBD with a compound heterozygous IL-10 receptor alpha subunit (IL-10RA) mutation, one of which was paternally-inherited and the other occurring de novo. METHODS Deep sequencing of IL-10, IL-10RA...
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BACKGROUND/AIMS Inflammatory bowel disease is commonly accompanied by colonic dysmotility and causes changes in intestinal smooth muscle contractility. In this study, colonic smooth muscle contractility in a chronic inflammatory condition was investigated using smooth muscle tissues prepared from interleukin-10 knockout (IL-10(-/-)) mice. METHODS Prepared smooth muscle sections were placed in...
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ژورنال
عنوان ژورنال: International Journal of Current Research and Review
سال: 2018
ISSN: 2231-2196,0975-5241
DOI: 10.31782/ijcrr.2018.10902